“But statistical significance does not mean clinically meaningful,” said Dr. A pooled meta-analysis of a number of small clinical studies on berberine’s impact on cardiovascular risk factors, including obesity, found a very small, but statistically significant weight loss benefit. That doesn’t mean that the herb has no impact at all on the body’s metabolic systems, however. Is berberine’s weight loss effect meaningful? “As for it being nature’s Ozempic, there’s no evidence to suggest that is true,” added Apovian, who was the lead author for the Endocrine Society’s clinical practice guidelines for the pharmacological management of obesity. Caroline Apovian, a professor of medicine at Harvard Medical School and codirector of the Center for Weight Management and Wellness at Brigham and Women’s Hospital in Boston. So, you have to be very careful,” said Dr. “That’s the problem with berberine and all of these herbal substances - they’re typically not rigorously studied in the type of large, randomized clinical trials that we put actual drugs through. As an extract from plants such as goldenseal, barberry and various poppies, berberine is considered a dietary supplement by the US Food and Drug Administration and is thus regulated as a food, not a drug. Some medical experts CNN spoke with, however, had concerns about the use of this unregulated supplement. “Berberine has become my new BFF because it has been helping me with my weight loss,” one believer gushed, adding that one of the herbal supplement’s manufacturers is offering her - and a few of her lucky viewers - a year’s supply. Some manufacturers are jumping on the trend. Using berberine as a supplement has become so trendy, in fact, that it has been dubbed “ Nature’s Ozempic” by social media users. If TikTok and Reddit influencers are to be believed, the plant-based compound called berberine can be a replacement for such popular diabetes and weight loss drugs as Ozempic and Wegovy.
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